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Antiproliferative Betti Bases and Prodrugs Thereof

Betti base drugs and prodrugs optimized to enhance their antiproliferative activity through inhibition of MDM2, MDMX, p53, E3 ligase and FTH1. Background: Betti bases are a family of small organic molecules composed of phenolic or hydroxyarl benzylic amine derivatives. These molecules have established antiproliferative effects on various cancer cell...
Published: 2/2/2024   |   Inventor(s): Sherry Chemler, Xinjiang Wang, Samuel Galster, Rati Lama
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures

A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal. Background: Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 2/2/2024   |   Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering

Compositions and Methods to Promote Endothelialization of Cardiovascular Implants

Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility. Background: A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 2/2/2024   |   Inventor(s): Stelios Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering

Shear-Thinning Hydrogels

­Shear-thinning, biocompatible hydrogels that are useful for cell therapy and which hold promise for 3D printing of functional tissue constructs. Background: While hydrogels hold great promise in applications such as drug delivery and tissue engineering, their fast gelation kinetics restrict their use in injectable applications such as the delivery...
Published: 2/7/2024   |   Inventor(s): Stelios Andreadis, Mohamed Mohamed
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

Fast Projection Stereolithography Printing of Large-Scale Biocompatible Hydrogels

3D Fast Hydrogel Stereolithography (FLOAT) Printing for rapid organ production. Background: Sadly time does not heal all wounds. As the years accumulate, more and more body parts are damaged or lost. Replacement of these parts by transplantation has produced a mixed bag. The adaptation of 3D-printing to biological tissues offers the hope of manufactured...
Published: 2/2/2024   |   Inventor(s): Ruogang Zhao, Chi Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents

DrawGlycan - Rendering Glycans from Mass Spectrometry Data

Simple and robust tool to render glycans from mass spectrometry data using SNFG standards. Background: Glycomics, the study of glycans in proteomic mass spectrometry, is used in basic science to understand the signaling and interaction between cells, especially those involved in immunology, oncology, and infectious disease. It also has important...
Published: 4/5/2023   |   Inventor(s): Sriram Neelamegham, Kai Cheng
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Bioinformatics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Instrumentation, Technology Classifications > Biomedical Science and Engineering

X-ray Attenuator System for ROI Imaging

A mechanical shutter-like attenuator with advanced image processing to equalize image brightness for region of interest real-time processing while reducing exposure to radiation.One of the primary concerns with radiographic and fluoroscopic imaging is minimizing potentially harmful effects of ionizing radiation while still maintaining image quality....
Published: 4/5/2023   |   Inventor(s): Stephen Rudin
Keywords(s): Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Imaging, Technology Classifications > Instrumentation, Technology Classifications > Medical Devices, Campus > University at Buffalo

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