Cerebral organoid technology for diagnostics and treatment of schizophrenia


Schizophrenia is a complex disorder which usually manifests itself after puberty.  However it is believed the neurological basis of the disorder is already in place in utero.  As early diagnosis would allow earlier intervention, brain organoids derived schizophrenic patients were examined.  Organoids are created from induced pluripotent stem cells (iPSCs) derived from patients.  Normal iPSCs can be grown into cellular masses which model early brain development.  The iPSCs from schizophrenic patients produce disorganized organoids.  The morphological differences and gene expression patterns are diagnostic of schizophrenia.

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For Information, Contact:
Michael Fowler
Commercialization Manager
University at Buffalo
Michal Stachowiak
Ewa Stachowiak
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