Method to Remove Transition Metals from Chemical Reactions


Despite the ubiquitous use of metal catalysts, their removal and recovery from post-reaction mixtures remains a major concern. Traditional removal methods such as chromatography, activated carbon, extraction, distillation and recrystallization are less than ideal, either because they do not effectively remove metal impurities or require significant time and effort, which are particularly costly during large scale synthetic procedures. There is a clear and present need for effective methods for the removal and recovery of metal catalysts from solution. Chemists at the University at Buffalo have developed a solid supported system and methods for sequestering and removing such catalysts from solution. Preliminary studies in which the system was used to remove ruthenium from metathesis reactions demonstrated its ability to achieve near complete (up to 99.99%) removal of residual ruthenium under a variety of reaction conditions. By facilitating the removal of ruthenium-based catalysts to levels as low as single digit ppm, this system could enable more widespread use of such catalysts in pharmaceutical processes. Beyond ruthenium, the system is also effective for the removal of other transition metals including but not limited to palladium and iridium. More

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For Information, Contact:
Timothy Dee
Associate Director
University at Buffalo
Steven Diver
Jonathan French
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