Methods for Cross-Linking Bioactive Peptides and Proteins and Uses Thereof


Despite their excellent bioactivity, peptides are rarely good drug candidates because they cannot penetrate the cell membrane to reach their intracellular target. This technology provides a new cross-linking chemistry (i.e. peptide stapling chemistry) that dramatically improves cell permeability of bioactive peptides. More specifically, the chemistry entails a new class of rigid cysteine cross-linkers that do not impart a significant addition of mass to the bioactive peptide.

Related publications: Chem. Commun., 2011, 47, 9396–9398

See also: R-6331 and R-6631 

Patent Information:
For Information, Contact:
Timothy Dee
Associate Director
University at Buffalo
Qing Lin (UB)
Avinash Muppidi
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