Methods for Cross-Linking Bioactive Peptides and Proteins and Uses Thereof

Description:

Despite their excellent bioactivity, peptides are rarely good drug candidates because they cannot penetrate the cell membrane to reach their intracellular target. This technology provides a new cross-linking chemistry (i.e. peptide stapling chemistry) that dramatically improves cell permeability of bioactive peptides. More specifically, the chemistry entails a new class of rigid cysteine cross-linkers that do not impart a significant addition of mass to the bioactive peptide.

Related publications: Chem. Commun., 2011, 47, 9396?9398

See also: R-6331 and R-6631 

Patent Information:
For Information, Contact:
Timothy Dee
Commercialization Manager
University at Buffalo
716-645-8139
tpdee@buffalo.edu
Inventors:
Qing Lin (UB)
Avinash Muppidi
Keywords:
Technology
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