Injectable Hydrogel System Designed to Prolong Joint Retention in Osteoarthritis
An injectable hydrogel platform that forms a lubricious depot in the joint after a single minimally invasive injection, enabling multi-week retention and sustained release of drug-loaded nanocarriers.
BACKGROUND:
Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Current intra-articular standards of care, such as analgesics,...
Published: 10/7/2026
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Inventor(s): Jonathan Lovell, Zachary Varrenti, Ramkumar Tiruvannamalai Annamalai, Yiting Song
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
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Chemical Modifications of Substrates Using Zwitterionic-Functionalized Dendrimers
Novel platform for biomaterials development with advanced physiological properties
BACKGROUND:
The need for improved biomaterials is a continuous challenge in the clinical field. Extended physiological circulation times, reduced immune responses, and lowered cytotoxicity are a few parameters crucial for therapeutic and diagnostic biomaterials. ...
Published: 8/31/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Functionalized Dendrimers with Regioselective Reactivity
Novel compositions of zwitterionic dendrimers and derived polymers
BACKGROUND:
There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials.
TECHNOLOGY...
Published: 10/7/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics
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Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs.
Background:
Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 10/7/2026
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Inventor(s): Sriram Neelamegham, Qi Yang
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Stable Micelle Drug Formulations
Method for producing stable, concentrated drug micelles that reduce or eliminate surfactants from drug formulations.
Background:
Hydrophobic drugs comprise a substantial proportion of all pharmaceutical compounds in use today. These drugs have limited solubility in water. There are numerous strategies for addressing solubility; however, for many...
Published: 8/31/2026
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Inventor(s): Jonathan Lovell, Wentao Song, Yumiao Zhang
Keywords(s): Technologies
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Campus > University at Buffalo
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