mAbs Inhibit Human RAGE by Blocking Its Binding to Heparan Sulfate
Monoclonal antibodies that block heparan sulfate binding to human RAGE, preventing its activation in disease states to serve as a therapeutic treatment.
Background:
Receptor for Advanced Glycation End products (RAGE), a widely expressed inflammatory receptor for disease states such as atherosclerosis, cancer, Alzheimer disease, drug-induced liver...
Published: 3/8/2024
|
Inventor(s): Ding Xu, Chih Yean Ong, Miaomiao Li
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
|
Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios.
Background:
While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 2/2/2024
|
Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
|
Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal.
Background:
Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 2/2/2024
|
Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
|
Targeted delivery of matrix-modulating enzymes
For enhanced monoclonal antibody uptake and distribution in solid tumors.
Background:
Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...
Published: 2/2/2024
|
Inventor(s): Joseph Balthasar, Brandon Bordeau
Keywords(s): Technologies
Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
|