Production of Salivary Gland Epithelial Progenitors and Acinar Organoids
Human UPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function.
Background:
Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 3/8/2024
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Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays
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Method for In Vivo Detection of Cell-Surface Disease Markers
A pair of compatible reagents, one antibody-based biomarker target and one small molecule PET tracer, combine to provide a high affinity, disease specific detection system.
Background:
The medical diagnostics industry has an urgent demand for efficient non-invasive biomarkers to diagnosis and stage disease progression for cancer and Alzheimer's...
Published: 2/7/2024
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Inventor(s): Qing Lin, Ming Fang, Gangam Kumar
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging
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Targeted delivery of matrix-modulating enzymes
For enhanced monoclonal antibody uptake and distribution in solid tumors.
Background:
Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...
Published: 2/2/2024
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Inventor(s): Joseph Balthasar, Brandon Bordeau
Keywords(s): Technologies
Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo
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DrawGlycan - Rendering Glycans from Mass Spectrometry Data
Simple and robust tool to render glycans from mass spectrometry data using SNFG standards.
Background:
Glycomics, the study of glycans in proteomic mass spectrometry, is used in basic science to understand the signaling and interaction between cells, especially those involved in immunology, oncology, and infectious disease. It also has important...
Published: 4/5/2023
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Inventor(s): Sriram Neelamegham, Kai Cheng
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Bioinformatics, Technology Classifications > Research Tools and Reagents, Technology Classifications > Instrumentation, Technology Classifications > Biomedical Science and Engineering
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Traveling Wave Actuators for Flow Control
A piezoelectric actuator surface that generates traveling waves for active flow control has been developed and can be used to remove, reduce, or control flow separation.
Background:
Flow separation is typically associated with significant energy loss in engineering applications. For example, flow separation decreases lift and increases drag...
Published: 3/22/2024
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Inventor(s): M. Amin Karami, Iman Borazjani (non-RF)
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Engineering, Technology Classifications, Technology Classifications > Energy Conservation
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