Antiproliferative Betti Bases and Prodrugs Thereof
Betti base drugs and prodrugs optimized to enhance their antiproliferative activity through inhibition of MDM2, MDMX, p53, E3 ligase and FTH1.
Background:
Betti bases are a family of small organic molecules composed of phenolic or hydroxyarl benzylic amine derivatives. These molecules have established antiproliferative effects on various cancer cell...
Published: 2/2/2024
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Inventor(s): Sherry Chemler, Xinjiang Wang, Samuel Galster, Rati Lama
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Method for In Vivo Detection of Cell-Surface Disease Markers
A pair of compatible reagents, one antibody-based biomarker target and one small molecule PET tracer, combine to provide a high affinity, disease specific detection system.
Background:
The medical diagnostics industry has an urgent demand for efficient non-invasive biomarkers to diagnosis and stage disease progression for cancer and Alzheimer's...
Published: 2/7/2024
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Inventor(s): Qing Lin, Ming Fang, Gangam Kumar
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Healthcare, Technology Classifications > Medical Imaging
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Robotic Gripper with Variable Stiffness Actuators
A robotic gripper with variable stiffness actuators improves the safety and robustness of the grasp and enhances dynamic manipulation.
Background:
The reliable grasping and handling of objects is essential to industrial and service robots for physical human-robot interaction (pHRI). Moreover, safety becomes an important issue when a robot needs...
Published: 3/22/2024
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Inventor(s): Ehsan Esfahani, Amirhossein Hajiagha Memar
Keywords(s): Assistive Technology, Robotics, Technologies
Category(s): Technology Classifications > Engineering, Technology Classifications > Assistive Technology, Technology Classifications > Healthcare, Campus > University at Buffalo
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Smart Health Monitoring & Diagnosis System Based on Wearable Nano-biosensing Networks
This invention is comprised of a flexible bio-photonic sensing implant and an external wearable device capable of activating and obtaining data from the implant.
Background:
In the last decade, major advancements in the field of micro & nano electronics, photonics, electro-mechanical systems and wireless communication technologies have enabled...
Published: 2/2/2024
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Inventor(s): Josep Jornet, Liang Feng, Ed Furlani (Deceased), Qiaoqiang Gan, Zhi Sun, Yun Wu
Keywords(s): Technologies
Category(s): Technology Classifications > Healthcare, Technology Classifications > Information Technology, Campus > University at Buffalo
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A Novel Marker for Detection of Prostate Cancer
Myosine IC isoform A is overexpressed in prostate cancer tissues and metastatic cells. The monoclonal antibodies and PCR tools developed here detect overexpression. In 2012 a novel isoform of myosine IC designated isoform A was discovered. Several years later tissue distribution studies discovered it was overexpressed in prostate cancer tissues and...
Published: 2/12/2024
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Inventor(s): Wilma Hofmann
Keywords(s): Technologies
Category(s): Technology Classifications > Healthcare, Campus > University at Buffalo, Technology Classifications > Diagnostics
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Solid Supported Metal-Scavenging Agents
Compositions and methods for sequestration and removal of transition metal complexes (e.g. catalysts) from solution.
Background:
Despite the wide use of transition metal catalysts in chemical processes across a variety of industries, their removal and recovery from post-reaction mixtures remains a major challenge. Traditional removal methods...
Published: 3/5/2024
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Inventor(s): Steven Diver, Jonathan French
Keywords(s): TAF, Technologies
Category(s): Technology Classifications > Healthcare, Technology Classifications > Materials and Chemicals, Campus > University at Buffalo
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