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Development of Lectins with Protein Engineering

Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue. Background: Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024   |   Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays

Production of Salivary Gland Epithelial Progenitors and Acinar Organoids

Human iPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function. Background: Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 6/28/2024   |   Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays

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