Ambient-Temperature Direct Air Capture of Carbon Dioxide
Novel amine-based sorbents for carbon dioxide capture with enhanced oxidative and thermal stability
BACKGROUND:
Anthropogenic climate change presents an urgent threat to ecosystems, public health and economic stability. Even single degree increases in global temperatures can trigger irreversible impacts, ranging from biodiversity loss and food insecurity...
Published: 3/3/2026
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Inventor(s): Miao Yu, Kaleb Friedman
Keywords(s): Chemistry, Energy, Environment, Featured, Materials & Chemicals, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Environment, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Method to Determine Quality of Mitochondrial Cargo in Extracellular Vesicles
A novel method that measures mitochondrial membrane potential in extracellular vesicles, providing a direct readout of mitochondrial quality and utility.
Background:
Studies have shown that EV-mediated intercellular communication is influenced, at least in part, by the mitochondrial cargo contained within EVs. This highlights the importance of rigorous...
Published: 2/19/2026
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Inventor(s): Barbara Alevriadou, Zahid Manzar, Hans Minderman
Keywords(s): Biotechnology, Diagnostic, Healthcare, Pharmaceutical, Research Tool, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases
Background:
Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 2/19/2026
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Featured, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs.
Background:
Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 2/19/2026
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Inventor(s): Sriram Neelamegham, Qi Yang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Borophene Tubes
Nanotubes directly synthesized from atomically thin sheets of borophene to adopt multiple structures with high thermal and electrical conductivity.
Background:
Borophene nanotubes (BNT) have been a synthetic goal for decades based on predictions of their usefulness in energy storage and generation. BNTs offer options for carbon nanotubes applications,...
Published: 2/19/2026
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Inventor(s): Paras Prasad, Mark Swihart, Pranay Ranjan, Devendra Negi, Amitava Banerjee, Shahzad Ahmad, Moin Siddiqui, Arshiya Ansari, Ghanshyam Varshney
Keywords(s): Chemistry, Featured, Materials & Chemicals, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Materials and Chemicals, Technology Classifications > Engineering
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Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 2/19/2026
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Modified Graphene Oxide-based Membranes for Mixture Separations
A facile method for developing membranes for hydrocarbon mixture separations by depositing graphene oxide flakes on a commercial porous substrate.
Background:
Molecular separations in mixtures account for approximately 50% of industrial energy use in the US alone, so there is high demand for alternate separation technologies, particularly for liquid...
Published: 2/19/2026
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Inventor(s): Miao Yu, Bratin Sengupta
Keywords(s): Chemistry, Featured, Materials & Chemicals, Research Tool, Surface Research, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Benzodiazepinone-derived Inhibitors of EGFR and HER2
A class of benzodiazepinone-derived molecules, inhibitors of both triple mutant EGFR and HER2, for cancer therapeutics or biochemical research tools.
Background:
Inhibition of epithelial growth factor receptor (EGFR) as a non-small cell lung cancer (NSCLC) therapeutic is not a new concept, but 75% of patients die within five years of diagnosis. As...
Published: 2/19/2026
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Inventor(s): David Heppner, Stefan Laufer, Florian Wittlinger, Blessing Ogboo, Calvin Pham, Alexander Rasch
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Materials and Chemicals, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Research Tools and Reagents
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Tool for Predicting Clinical Immunogenicity
An in vitro tool for predicting clinical immunogenicity of subcutaneously administered therapeutic proteins.
Background:
Immunogenicity, the propensity of a product to elicit an immune response to itself or related structures, has the potential to reduce or eliminate the therapeutic benefit it is intended to provide, and may even lead to adverse...
Published: 2/19/2026
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Inventor(s): Sathy Balu-Iyer, Nicole Jarvi
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Fast Projection Stereolithography Printing of Large-Scale Biocompatible Hydrogels
3D Fast Hydrogel Stereolithography (FLOAT) Printing for rapid organ production.
Background:
Sadly time does not heal all wounds. As the years accumulate, more and more body parts are damaged or lost. Replacement of these parts by transplantation has produced a mixed bag. The adaptation of 3D-printing to biological tissues offers the hope of manufactured...
Published: 2/19/2026
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Inventor(s): Ruogang Zhao, Chi Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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