Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Continuous Ammonia Production from Air
An integrated system with a cascading plasma electrochemical process to generate ammonia at room temperature and pressure, using water as the proton source, significantly lowering the carbon footprint while providing the highest ammonia production rate among the reported literature.
Background:
Ammona synthesis is a fundamental reaction for the production...
Published: 9/14/2024
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Inventor(s): Yuguang Li, Xiaoli Ge
Keywords(s): Chemistry, Energy, Environment, Featured, Instrumentation, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Clean Energy, Technology Classifications > Engineering, Technology Classifications > Energy, Technology Classifications > Environment, Technology Classifications > Instrumentation, Technology Classifications > Research Tools and Reagents
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Modified Graphene Oxide-based Membranes for Mixture Separations
A facile method for developing membranes for hydrocarbon mixture separations by depositing graphene oxide flakes on a commercial porous substrate.
Background:
Molecular separations in mixtures account for approximately 50% of industrial energy use in the US alone, so there is high demand for alternate separation technologies, particularly for liquid...
Published: 4/10/2024
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Inventor(s): Miao Yu, Bratin Sengupta
Keywords(s): Chemistry, Featured, Materials & Chemicals, Research Tool, Surface Research, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Tool for Predicting Clinical Immunogenicity
An in vitro tool for predicting clinical immunogenicity of subcutaneously administered therapeutic proteins.
Background:
Immunogenicity, the propensity of a product to elicit an immune response to itself or related structures, has the potential to reduce or eliminate the therapeutic benefit it is intended to provide, and may even lead to adverse...
Published: 8/21/2024
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Inventor(s): Sathy Balu-Iyer, Nicole Jarvi
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Fast Projection Stereolithography Printing of Large-Scale Biocompatible Hydrogels
3D Fast Hydrogel Stereolithography (FLOAT) Printing for rapid organ production.
Background:
Sadly time does not heal all wounds. As the years accumulate, more and more body parts are damaged or lost. Replacement of these parts by transplantation has produced a mixed bag. The adaptation of 3D-printing to biological tissues offers the hope of manufactured...
Published: 2/2/2024
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Inventor(s): Ruogang Zhao, Chi Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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Faster 3D Photoacoustic Tomography with Improved Elevation Resolution
A solution to the problems posed by both traditional 3D PAT imaging and biopsies for dense breast tissue and skin imaging.
Background:
Traditional scanning schemes for three-dimensional photoacoustic tomography (PAT) have failed to address the issue of long scanning times and low elevation resolution, contributing to patient discomfort and limiting...
Published: 10/7/2024
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Inventor(s): Jun Xia, Yuehang Wang
Keywords(s): Technologies
Category(s): Technology Classifications > Imaging, Technology Classifications > Research Tools and Reagents, Campus > University at Buffalo
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Small Molecule Imaging of Fungi by PET Scanning
Isotopically-labeled calcofluor derivatives to differentiate fungal lung infections from bacterial or cancer nodules in immunosuppressed patients by PET scanning. This relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi including Aspergillus species, such as by...
Published: 5/29/2024
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Inventor(s): John Panepinto, Peter Williamson, Dale Kiesewetter, Jin Qiu
Keywords(s): Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Campus > University at Buffalo, Technology Classifications > Diagnostics
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Monoclonal Antibody 3F5-5E5 and P107 Diagnostic Markers and Putative Vaccine Antigen for Moraxella Catarrhalis and Supplemental Mab 4G5
Monoclonal antibodies, proteins, nucleic acid sequences and lipoologosaccharides specific to Moraxella catarrhalis. These materials are useful for designing a much-needed diagnostic test. This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These...
Published: 5/8/2024
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Inventor(s): Anthony Campagnari, Kristin Furano, Amy Howlett, Nicole Luke-Marshall
Keywords(s): Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Campus > University at Buffalo, Technology Classifications > Diagnostics
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