Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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High-Frequency, Device-Free mmWave Facial Landmark Sensing
A high-resolution, non-contact facial landmark tracking system that uses millimeter wave (mmWave) technology to achieve precise and efficient facial sensing.
Background:
MicroFace introduces a novel mmWave-based system for high-resolution, non-contact facial landmark tracking. This system addresses the existing challenge of precise and efficient...
Published: 9/10/2024
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Inventor(s): Wenyao Xu, Chenhan Xu
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Sensors, Technology Classifications > Information Technology
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Cross Finger Biometric Verification
Improved digital authentication systems that allow users to enroll with one finger and unlock with any other finger.
Background:
Fingerprints have long been regarded as one of the most reliable forms of biometric identification due to their presumed uniqueness. The distinct patterns and ridges on each individual's fingertips have served as a...
Published: 5/10/2024
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Inventor(s): Wenyao Xu, Hod Lipson, Aniv Ray, Gabriel Guo
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Information Technology
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Antiproliferative Betti Bases and Prodrugs Thereof
Betti base drugs and prodrugs optimized to enhance their antiproliferative activity through inhibition of MDM2, MDMX, p53, E3 ligase and FTH1.
Background:
Betti bases are a family of small organic molecules composed of phenolic or hydroxyarl benzylic amine derivatives. These molecules have established antiproliferative effects on various cancer cell...
Published: 8/13/2024
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Inventor(s): Sherry Chemler, Xinjiang Wang, Samuel Galster, Rati Lama
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
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Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal.
Background:
Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 7/9/2024
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Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
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Compositions and Methods to Promote Endothelialization of Cardiovascular Implants
Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility.
Background:
A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 8/9/2024
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Inventor(s): Stelios Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering
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Shear-Thinning Hydrogels
Shear-thinning, biocompatible hydrogels that are useful for cell therapy and which hold promise for 3D printing of functional tissue constructs.
Background:
While hydrogels hold great promise in applications such as drug delivery and tissue engineering, their fast gelation kinetics restrict their use in injectable applications such as the delivery...
Published: 8/21/2024
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Inventor(s): Stelios Andreadis, Mohamed Mohamed
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Fast Projection Stereolithography Printing of Large-Scale Biocompatible Hydrogels
3D Fast Hydrogel Stereolithography (FLOAT) Printing for rapid organ production.
Background:
Sadly time does not heal all wounds. As the years accumulate, more and more body parts are damaged or lost. Replacement of these parts by transplantation has produced a mixed bag. The adaptation of 3D-printing to biological tissues offers the hope of manufactured...
Published: 2/2/2024
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Inventor(s): Ruogang Zhao, Chi Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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X-ray Attenuator System for ROI Imaging
A mechanical shutter-like attenuator with advanced image processing to equalize image brightness for region of interest real-time processing while reducing exposure to radiation.One of the primary concerns with radiographic and fluoroscopic imaging is minimizing potentially harmful effects of ionizing radiation while still maintaining image quality....
Published: 4/5/2023
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Inventor(s): Stephen Rudin
Keywords(s): Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Imaging, Technology Classifications > Instrumentation, Technology Classifications > Medical Devices, Campus > University at Buffalo
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