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High-Density Neurostimulation System

High-density cluster electrode technology that enables a high degree of scalability and customization for neurostimulation applications Background: Existing skin-surface neurostimulation is achieved by a single electrode that performs bulk stimulation on the entire tissue in the neurostimulation area. It does not have the capability to control the...
Published: 10/7/2026   |   Inventor(s): Filip Stefanovic, Albert Titus
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Assistive Technology, Technology Classifications > Medical Devices

Injectable Hydrogel System Designed to Prolong Joint Retention in Osteoarthritis

An injectable hydrogel platform that forms a lubricious depot in the joint after a single minimally invasive injection, enabling multi-week retention and sustained release of drug-loaded nanocarriers. BACKGROUND: Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Current intra-articular standards of care, such as analgesics,...
Published: 10/7/2026   |   Inventor(s): Jonathan Lovell, Zachary Varrenti, Ramkumar Tiruvannamalai Annamalai, Yiting Song
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines

Liquid Biopsy Detection of TF-Ag-α-Positive Cancer-Associated Exosomes

A liquid biopsy assay detecting TF-Ag-α–positive tumor-derived exosomes for cancer screening, early detection and treatment monitoring. Background: Cancer diagnostics are rapidly evolving as early detection and treatment monitoring are critical to improving patient outcomes. Traditional methods such as imaging and tissue biopsies...
Published: 10/7/2026   |   Inventor(s): Yun Wu, Grace Dy, Kate Rittenhouse-Olson
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Engineering, Technology Classifications > Medical Devices, Technology Classifications > Sensors

Reduction of Lipid Accumulation Reverses Aging

Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis. Background: Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 10/7/2026   |   Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines

Functionalized Dendrimers with Regioselective Reactivity

Novel compositions of zwitterionic dendrimers and derived polymers BACKGROUND: There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials. TECHNOLOGY...
Published: 10/7/2026   |   Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics

A Flexible Multiplexed Amplifier for Multichannel Wearable Biopotential Devices

A compact, multiplexed amplifier architecture for wearable biopotential devices, enabling efficient, multi-channel data processing in a miniaturized, flexible format. Background: High-density biopotential measurement devices, such as EMGs and EEGs, typically require large and cumbersome amplifiers, limiting their applicability in wearable technologies....
Published: 10/7/2026   |   Inventor(s): Filip Stefanovic
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Medical Devices, Technology Classifications > Electronics

High-Frequency, Device-Free mmWave Facial Landmark Sensing

A high-resolution, non-contact facial landmark tracking system that uses millimeter wave (mmWave) technology to achieve precise and efficient facial sensing. Background: MicroFace introduces a novel mmWave-based system for high-resolution, non-contact facial landmark tracking. This system addresses the existing challenge of precise and efficient...
Published: 10/7/2026   |   Inventor(s): Wenyao Xu, Chenhan Xu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Sensors, Technology Classifications > Information Technology

Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures

A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal. Background: Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 10/7/2026   |   Inventor(s): Qiang Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering

Compositions and Methods to Promote Endothelialization of Cardiovascular Implants

Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility. Background: A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 8/31/2026   |   Inventor(s): Stylianos Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering

Development of Lectins with Protein Engineering

Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue. Background: Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 8/31/2026   |   Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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