Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 1/28/2025
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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High-Frequency, Device-Free mmWave Facial Landmark Sensing
A high-resolution, non-contact facial landmark tracking system that uses millimeter wave (mmWave) technology to achieve precise and efficient facial sensing.
Background:
MicroFace introduces a novel mmWave-based system for high-resolution, non-contact facial landmark tracking. This system addresses the existing challenge of precise and efficient...
Published: 1/28/2025
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Inventor(s): Wenyao Xu, Chenhan Xu
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Sensors, Technology Classifications > Information Technology
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Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures
A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal.
Background:
Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....
Published: 2/12/2025
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Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering
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Compositions and Methods to Promote Endothelialization of Cardiovascular Implants
Provided here are fusion proteins that, when immobilized on the (blood-facing) surface of a cardiovascular implant, promote endothelialization, which is critical for long-term biocompatibility.
Background:
A major challenge to the clinical utilization and success of off-the-shelf vascular grafts (e.g. decellularized, devitalized and non-biologic/polymeric...
Published: 3/21/2025
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Inventor(s): Stelios Andreadis, Randall Smith, Bita Nasiri
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering
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Shear-Thinning Hydrogels
Shear-thinning, biocompatible hydrogels that are useful for cell therapy and which hold promise for 3D printing of functional tissue constructs.
Background:
While hydrogels hold great promise in applications such as drug delivery and tissue engineering, their fast gelation kinetics restrict their use in injectable applications such as the delivery...
Published: 1/28/2025
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Inventor(s): Stelios Andreadis, Mohamed Mohamed
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Fast Projection Stereolithography Printing of Large-Scale Biocompatible Hydrogels
3D Fast Hydrogel Stereolithography (FLOAT) Printing for rapid organ production.
Background:
Sadly time does not heal all wounds. As the years accumulate, more and more body parts are damaged or lost. Replacement of these parts by transplantation has produced a mixed bag. The adaptation of 3D-printing to biological tissues offers the hope of manufactured...
Published: 1/28/2025
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Inventor(s): Ruogang Zhao, Chi Zhou
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents
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X-ray Attenuator System for ROI Imaging
A mechanical shutter-like attenuator with advanced image processing to equalize image brightness for region of interest real-time processing while reducing exposure to radiation.One of the primary concerns with radiographic and fluoroscopic imaging is minimizing potentially harmful effects of ionizing radiation while still maintaining image quality....
Published: 4/5/2023
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Inventor(s): Stephen Rudin
Keywords(s): Technologies
Category(s): Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Imaging, Technology Classifications > Instrumentation, Technology Classifications > Medical Devices, Campus > University at Buffalo
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