Language-Agnostic Voice Biomarker Platform for Early Detection of Alzheimer’s Disease and Related Dementias (GloVoAD)
This technology enables early, non-invasive detection of Alzheimer’s disease and related dementias using a large-scale multilingual voice dataset and language-agnostic AI models that analyze vocal biomarkers without relying on speech transcription.
BACKGROUND:
Early detection of Alzheimer’s disease and related dementias (ADRD) remains...
Published: 4/16/2026
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Inventor(s): Wei Bo, Wenyao Xu, Aditya Challamarad, Harry Lin
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Artificial Intelligence, Technology Classifications > Diagnostics
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Chemical Modifications of Substrates Using Zwitterionic-Functionalized Dendrimers
Novel platform for biomaterials development with advanced physiological properties
BACKGROUND:
The need for improved biomaterials is a continuous challenge in the clinical field. Extended physiological circulation times, reduced immune responses, and lowered cytotoxicity are a few parameters crucial for therapeutic and diagnostic biomaterials. ...
Published: 4/16/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Functionalized Dendrimers with Regioselective Reactivity
Novel compositions of zwitterionic dendrimers and derived polymers
BACKGROUND:
There is a strong need for new classes of reactive reagents for the generation of novel materials with pre-defined characteristics. Here, new compounds can be generated employing properties associated with zwitterions, dendrimers, or combination materials.
TECHNOLOGY...
Published: 4/16/2026
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Inventor(s): Chong Cheng, Mingxuan Zhang, Yun Wu, Ziwen Zhang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics
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Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases
Background:
Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 4/16/2026
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 4/16/2026
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Stable Micelle Drug Formulations
Method for producing stable, concentrated drug micelles that reduce or eliminate surfactants from drug formulations.
Background:
Hydrophobic drugs comprise a substantial proportion of all pharmaceutical compounds in use today. These drugs have limited solubility in water. There are numerous strategies for addressing solubility; however, for many...
Published: 4/16/2026
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Inventor(s): Jonathan Lovell, Wentao Song, Yumiao Zhang
Keywords(s): Technologies
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Campus > University at Buffalo
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PCR Primers that Specifically Identify Moraxella Catarrhallis
PCR-based test to diagnose Moraxella Catarrhalis (MC) by amplifying a region of the MC chromosome and clone genes in serotype A, B and C.
M. Catarrhalis is a significant cause of human respiratory diseases and in particular is a major cause of otitis media in young children. The invention consists of PCR Primers that demonstrate quick and definitive...
Published: 4/16/2026
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Inventor(s): Anthony Campagnari, Katie Edwards, Nicole Luke-Marshall
Keywords(s): Technologies
Category(s): Technology Classifications > Diagnostics, Campus > University at Buffalo
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A Novel Marker for Detection of Prostate Cancer
Myosine IC isoform A is overexpressed in prostate cancer tissues and metastatic cells. The monoclonal antibodies and PCR tools developed here detect overexpression. In 2012 a novel isoform of myosine IC designated isoform A was discovered. Several years later tissue distribution studies discovered it was overexpressed in prostate cancer tissues and...
Published: 4/16/2026
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Inventor(s): Wilma Hofmann
Keywords(s): Technologies
Category(s): Technology Classifications > Healthcare, Campus > University at Buffalo, Technology Classifications > Diagnostics
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Detecting a Bacterial Process in Chronic Rhinosinusitis
By looking for bacterial markers this assay distinguishes the various forms of Chronic Rhinosinusitis for quicker and more accurate clinical treatments.
Chronic Rhinosinusitis (CRS) is an inflammatory disease involving the sinuses and nasal cavity which effects 32 million in the US. Differentiation between chronic and acute sinusitis would allow...
Published: 4/16/2026
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Inventor(s): Jens Ponikau, Hirohito Kita, David Sherris
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Campus > University at Buffalo, Technology Classifications > Diagnostics
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Small Molecule Imaging of Fungi by PET Scanning
Isotopically-labeled calcofluor derivatives to differentiate fungal lung infections from bacterial or cancer nodules in immunosuppressed patients by PET scanning. This relates to the field of radioactive, isotopically-labeled calcofluor derivatives and uses of such to detect fungi, such as filamentous fungi including Aspergillus species, such as by...
Published: 4/16/2026
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Inventor(s): John Panepinto, Peter Williamson, Dale Kiesewetter, Jin Qiu
Keywords(s): Technologies
Category(s): Technology Classifications > Research Tools and Reagents, Campus > University at Buffalo, Technology Classifications > Diagnostics
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