Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 11/20/2024
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Production of Salivary Gland Epithelial Progenitors and Acinar Organoids
Human iPSC-based tissue engineering system to develop salivary gland epithelial progenitors used to construct acinar organoids that mimic glandular microarchitecture and function.
Background:
Organoids are three-dimensional cell constructs that replicate the complicated tissue microarchitecture of specialized epithelial tissues. These constructs...
Published: 6/28/2024
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Inventor(s): Stelios Andreadis, Ronel Samuel, Olga Baker, Kihoon Nam
Keywords(s): Biomedical Engineering, Biotechnology, Featured, Medical Devices, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications, Technology Classifications > Biological Materials, Technology Classifications > Screens and Assays
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NeuroSTREAM
This program measures brain atrophy using fluid-attenuated inversion recovery (FLAIR) images of the lateral ventricular volume (LVV) region of the brain.
High quality MRI scans are used to measure brain atrophy. However these scans are not always available or current but it is vital to know the patients status with regards to brain atrophy. This...
Published: 4/5/2023
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Inventor(s): Michael Dwyer, Robert Zivadinov
Keywords(s): Technologies
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Medical Imaging, Technology Classifications > Screens and Assays, Campus > University at Buffalo
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Detecting a Bacterial Process in Chronic Rhinosinusitis
By looking for bacterial markers this assay distinguishes the various forms of Chronic Rhinosinusitis for quicker and more accurate clinical treatments.
Chronic Rhinosinusitis (CRS) is an inflammatory disease involving the sinuses and nasal cavity which effects 32 million in the US. Differentiation between chronic and acute sinusitis would allow...
Published: 5/7/2024
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Inventor(s): Jens Ponikau, Hirohito Kita, David Sherris
Keywords(s): Technologies
Category(s): Technology Classifications > Screens and Assays, Campus > University at Buffalo, Technology Classifications > Diagnostics
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