Glycosyltransferase Mutation-Activity Landscape
A streamlined high-throughput platform for engineering glycosyltransferases and glucosidases
Background:
Glycosyltransferases are enzymes that commonly transfer monosaccharides to proteins and lipid scaffolds. These enzymes constitute ~2% of the coding human genome, representing over 200 proteins. Mutations in glycosyltransferases lead to disease;...
Published: 9/12/2025
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Biotechnology, Diagnostic, Pharmaceutical, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Screens and Assays, Technology Classifications > Research Tools and Reagents, Technology Classifications > Biomedical Science and Engineering
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Method for Forming a Ceramic Aerogel
This technology is a scalable roll-to-roll (R2R) additive manufacturing of silica-carbon composite aerogel for building insulation materials that could exceed existing silica aerogel’s R-value at near standard temperature and pressure conditions and ~90% reduction of the unit price . The new composite is made of silica aerogel and carbon. The...
Published: 9/12/2025
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Inventor(s): Shenqiang Ren, Ruizhe Yang, Bingbo Chai
Keywords(s):
Category(s): Campus > University at Buffalo, Technology Classifications > Energy Conservation, Technology Classifications > Materials and Chemicals
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Self-Sustained Hydrogen Production
A self-sustained compact reactor for continuous hydrogen gas production from ammonia decomposition.
Background:
Hydrogen offers advantages as a clean and safe fuel for broad applications, but its storage and transport are expensive. Conversely, ammonia is an effective hydrogen carrier, as it contains 17.6% hydrogen by weight and can be economically...
Published: 9/12/2025
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Inventor(s): Amr Ibrahim, Miao Yu, Sung Hwan Park, Saman Emami Gerami
Keywords(s): Chemistry, Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Clean Energy, Technology Classifications, Technology Classifications > Energy, Technology Classifications > Engineering, Technology Classifications > Instrumentation, Technology Classifications > Materials and Chemicals
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Virus-Like Particles for mRNA Delivery
Virus-like particles have been engineered for drug delivery, gene editing applications, mRNA delivery and overcoming barriers in mouse lungs.
Background:
Recent biomedical research has shown increased interest in the use of virus-like particles as a drug delivery vehicle. Current viral vectors have been shown to cause adverse immunological responses,...
Published: 9/12/2025
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Inventor(s): Sriram Neelamegham, Qi Yang
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Gene Therapy, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Borophene Tubes
Nanotubes directly synthesized from atomically thin sheets of borophene to adopt multiple structures with high thermal and electrical conductivity.
Background:
Borophene nanotubes (BNT) have been a synthetic goal for decades based on predictions of their usefulness in energy storage and generation. BNTs offer options for carbon nanotubes applications,...
Published: 9/12/2025
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Inventor(s): Paras Prasad, Mark Swihart, Pranay Ranjan, Devendra Negi, Amitava Banerjee, Shahzad Ahmad, Moin Siddiqui, Arshiya Ansari, Ghanshyam Varshney
Keywords(s): Chemistry, Featured, Materials & Chemicals, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Materials and Chemicals, Technology Classifications > Engineering
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Development of Lectins with Protein Engineering
Lectins that exclusively bind sialylated core-2 O-linked glycans within cancerous tissue with a higher affinity than physiologically healthy tissue.
Background:
Lectins bind complex carbohydrates on cell surfaces and secreted glycoproteins. These carbohydrates are modified during disease from altered metabolism, though the proteins themselves are...
Published: 9/17/2025
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Inventor(s): Sriram Neelamegham, Ryoma Hombu
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Diagnostics, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays
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Modified Graphene Oxide-based Membranes for Mixture Separations
A facile method for developing membranes for hydrocarbon mixture separations by depositing graphene oxide flakes on a commercial porous substrate.
Background:
Molecular separations in mixtures account for approximately 50% of industrial energy use in the US alone, so there is high demand for alternate separation technologies, particularly for liquid...
Published: 9/12/2025
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Inventor(s): Miao Yu, Bratin Sengupta
Keywords(s): Chemistry, Featured, Materials & Chemicals, Research Tool, Surface Research, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Research Tools and Reagents
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Nanoporous Materials for Direct Air Capture
An amine-based ultrathin polyamide coating for direct carbon dioxide capture from air and point sources with low carbon dioxide concentrations.
Background:
Direct air capture (DAC) technologies allow extraction of carbon dioxide from the atmosphere and storage or conversion to value-added chemicals through catalysis. DAC materials must demonstrate...
Published: 9/12/2025
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Inventor(s): Miao Yu, Kaleb Friedman
Keywords(s): Chemistry, Energy, Featured, Materials & Chemicals, Research Tool, Surface Research, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Environment
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ALD-enabled High-Performance Membranes for Gas Separation
Polymer-based membranes developed with high H2/CO2 selectivity using facile surface nanoengineering for higher energy efficiency and lower cost production.
Background:
Isolation of CO2 from mixtures containing H2 is a critical gas separation, producing 94 million metric tons of H2 worldwide and valued at $170 billion in 2021. This market will continue...
Published: 9/12/2025
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Inventor(s): Haiqing Lin, Won-IL Lee, Chang-Yong Nam, Leiqing Hu, Kim Kisslinger, Vinh Bui, Ashwanth Subramanian
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Materials and Chemicals, Technology Classifications > Clean Energy, Technology Classifications > Environment
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Benzodiazepinone-derived Inhibitors of EGFR and HER2
A class of benzodiazepinone-derived molecules, inhibitors of both triple mutant EGFR and HER2, for cancer therapeutics or biochemical research tools.
Background:
Inhibition of epithelial growth factor receptor (EGFR) as a non-small cell lung cancer (NSCLC) therapeutic is not a new concept, but 75% of patients die within five years of diagnosis. As...
Published: 9/12/2025
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Inventor(s): David Heppner, Stefan Laufer, Florian Wittlinger, Blessing Ogboo, Calvin Pham, Alexander Rasch
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Materials and Chemicals
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