A Novel 14-3-3 Inhibitor to treat chronic pain
Inhibitor of 14-3-3 showing reduced ion-channel excitability in pain-sensing neurons and decreased pain behavior in mice, with no evidence of acute toxicity
Background:
14-3-3 proteins are small (28-30 kDa) acidic, highly-conserved proteins that comprise a family of seven isoforms in mammals. They are found throughout the cell and function in signaling...
Published: 10/8/2026
|
Inventor(s): Arindam Bhattacharjee, Rasheen Powell
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
|
Novel Small Molecule Anabolic Agents for Osteoporosis
Analogs of a naturally occurring phytoestrogen that hold promise for the treatment of osteoporosis and other conditions impacting peri- and post-menopausal women
Background:
Menopause significantly speeds bone loss and increases the risk of osteoporosis, a condition characterized by decreased bone mineral density and which impacts more than 200M people...
Published: 10/7/2026
|
Inventor(s): Bhaskar Das, Hiranmoy Das
Keywords(s): Featured, Pharmaceutical, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
|
Injectable Hydrogel System Designed to Prolong Joint Retention in Osteoarthritis
An injectable hydrogel platform that forms a lubricious depot in the joint after a single minimally invasive injection, enabling multi-week retention and sustained release of drug-loaded nanocarriers.
BACKGROUND:
Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Current intra-articular standards of care, such as analgesics,...
Published: 10/7/2026
|
Inventor(s): Jonathan Lovell, Zachary Varrenti, Ramkumar Tiruvannamalai Annamalai, Yiting Song
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Nanotechnology, Technology Classifications > Therapeutics and Vaccines
|
Potent Melatonin Receptor Ligands
Novel compounds for modulation of MT1 and/or MT2 receptor activity
Background:
Melatonin is an indoleamine hormone produced by the pineal gland. It is known primarily for its critical importance in regulating sleep promotion and circadian rhythms, however melatonin has also been implicated in a broad range of unique functions. These include: regulation...
Published: 10/7/2026
|
Inventor(s): Margarita Dubocovich, Andrew Tsotinis, Vasiliki Tsalakidou, Aikaterini Sakellaropoulou, Ioannis Papanastasiou, Marina Boniakou
Keywords(s): Featured, Pharmaceutical, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
|
Novel Antifungal Agents with Dual Mechanism of Action
With a clear and growing unmet need, a novel mechanism of action, and demonstrated in vitro superiority over current standard-of-care agents, these novel boron-based antifungal agents represent a compelling early-stage opportunity with significant commercial and public health relevance.
Background:
Invasive fungal infections caused by opportunistic...
Published: 10/7/2026
|
Inventor(s): Bhaskar Das, Joshua Nosanchuk, Daniel Miranda
Keywords(s): Chemistry, Featured, Healthcare, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
|
Novel Small Molecule Agents for Glioblastoma
Brain-penetrant small molecule agents possessing a dual targeting mechanism of action (LonP1 and CT-L proteasome inhibition) that may overcome resistance mechanisms that currently plague standard of care treatments for brain tumors such as glioblastoma.
Background:
Malignant astrocytomas, including glioblastoma (GBM), represent highly aggressive intracranial...
Published: 10/7/2026
|
Inventor(s): Bhaskar Das, Daniela Bota
Keywords(s): Chemistry, Nanotechnology, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
|
Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis.
Background:
Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 10/7/2026
|
Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
|
Apelin-Receptor (APJ) Antagonists
A series of stable, small molecule compounds that inhibit an alternative (non-VEGF) angiogenic pathway that is overexpressed in a variety of cancers.
Background:
Antiangiogenic drugs targeting the vascular endothelial growth factor (VEGF) signaling pathway are widely used to treat solid tumors and ocular conditions such as wet AMD. However, anti-VEGF...
Published: 8/31/2026
|
Inventor(s): Youngjae You, Sukyung Woo, Ganesh Bist, Ahmed Osama Mahmoud Abdel Elsheikh
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Design and Synthesis
|
Novel Fusion Protein Vaccine for Moraxella Catarrhalis Infections
A fusion protein vaccine designed to prevent COPD exacerbations and pediatric acute otitis media.
Background:
Respiratory infections caused by Moraxella catarrhalis (Mcat) represent a growing public health concern. In children, Mcat is a leading cause of otitis media, a common middle ear infection affecting most children by age three, frequently...
Published: 8/31/2026
|
Inventor(s): Timothy Murphy, Patricia Weber
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies
|
Antimicrobial Compositions and Combination Therapies
Compositions and methods to combat drug-resistant Pseudomonas aeruginosa infections.
Background:
Antibiotic resistance is an urgent and growing health threat. Pseudomonas aeruginosa is known to cause a variety of infections in both immunocompetent and immunocompromised individuals, but especially the latter. It utilizes both intrinsic and acquired...
Published: 8/31/2026
|
Inventor(s): Mark Sutton, Brian Tsuji, Anthony Berdis
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
|