Novel Antifungal Agents with Dual Mechanism of Action
With a clear and growing unmet need, a novel mechanism of action, and demonstrated in vitro superiority over current standard-of-care agents, these novel boron-based antifungal agents represent a compelling early-stage opportunity with significant commercial and public health relevance.
Background:
Invasive fungal infections caused by opportunistic...
Published: 7/24/2026
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Inventor(s): Bhaskar Das, Joshua Nosanchuk, Daniel Miranda
Keywords(s): Chemistry, Featured, Healthcare, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
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Novel Small Molecule Anabolic Agents for Osteoporosis
-Analogs of a naturally occurring phytoestrogen that hold promise for the treatment of osteoporosis and other conditions impacting peri- and post-menopausal women.
Background:
Menopause significantly speeds bone loss and increases the risk of osteoporosis, a condition characterized by decreased bone mineral density and which impacts more than 200M...
Published: 7/24/2026
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Inventor(s): Bhaskar Das, Hiranmoy Das
Keywords(s): Featured, Pharmaceutical, Research Tool, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
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Novel Small Molecule Agents for Glioblastoma
Brain-penetrant small molecule agents possessing a dual targeting mechanism of action (LonP1 and CT-L proteasome inhibition) that may overcome resistance mechanisms that currently plague standard of care treatments for brain tumors such as glioblastoma.
Background:
Malignant astrocytomas, including glioblastoma (GBM), represent highly aggressive intracranial...
Published: 7/10/2026
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Inventor(s): Bhaskar Das, Daniela Bota
Keywords(s): Chemistry, Nanotechnology, Pharmaceutical, Research Tool, Screening, Technologies, Therapeutic and Vaccines
Category(s): Campus > University at Buffalo, Technology Classifications > Drug Design and Synthesis, Technology Classifications > Therapeutics and Vaccines
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Reduction of Lipid Accumulation Reverses Aging
Therapeutic strategy to treat age-related cardiovascular disease and restore cardiovascular function through maintenance of lipid homeostasis.
Background:
Age is a key risk factor for cardiovascular disease such as atherosclerosis, which is characterized by endothelial dysfunction, extracellular matrix remodeling, lipid accumulation, chronic inflammation...
Published: 6/19/2026
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Inventor(s): Stylianos Andreadis, Yulun Wu, Pihu Mehrotra
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biological Materials, Technology Classifications > Healthcare, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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Apelin-Receptor (APJ) Antagonists
A series of stable, small molecule compounds that inhibit an alternative (non-VEGF) angiogenic pathway that is overexpressed in a variety of cancers.
Background:
Antiangiogenic drugs targeting the vascular endothelial growth factor (VEGF) signaling pathway are widely used to treat solid tumors and ocular conditions such as wet AMD. However, anti-VEGF...
Published: 6/19/2026
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Inventor(s): Youngjae You, Sukyung Woo, Ganesh Bist, Ahmed Osama Mahmoud Abdel Elsheikh
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Drug Design and Synthesis
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Novel Fusion Protein Vaccine for Moraxella Catarrhalis Infections
A fusion protein vaccine designed to prevent COPD exacerbations and pediatric acute otitis media.
Background:
Respiratory infections caused by Moraxella catarrhalis (Mcat) represent a growing public health concern. In children, Mcat is a leading cause of otitis media, a common middle ear infection affecting most children by age three, frequently...
Published: 6/19/2026
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Inventor(s): Timothy Murphy, Patricia Weber
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies
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Antimicrobial Compositions and Combination Therapies
Compositions and methods to combat drug-resistant Pseudomonas aeruginosa infections.
Background:
Antibiotic resistance is an urgent and growing health threat. Pseudomonas aeruginosa is known to cause a variety of infections in both immunocompetent and immunocompromised individuals, but especially the latter. It utilizes both intrinsic and acquired...
Published: 6/19/2026
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Inventor(s): Mark Sutton, Brian Tsuji, Anthony Berdis
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines
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Compositions and Methods for Increased Circulation Half-Life
Single domain antibody composition that enable half-life extension and increased blood:tissue ratios.
Background:
While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...
Published: 6/19/2026
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Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Duc Nguyen
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines
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Tool for Predicting Clinical Immunogenicity
An in vitro tool for predicting clinical immunogenicity of subcutaneously administered therapeutic proteins.
Background:
Immunogenicity, the propensity of a product to elicit an immune response to itself or related structures, has the potential to reduce or eliminate the therapeutic benefit it is intended to provide, and may even lead to adverse...
Published: 6/19/2026
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Inventor(s): Sathy Balu-Iyer, Nicole Jarvi
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
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Shear-Thinning Hydrogels
Shear-thinning, biocompatible hydrogels that are useful for cell therapy and which hold promise for 3D printing of functional tissue constructs.
Background:
While hydrogels hold great promise in applications such as drug delivery and tissue engineering, their fast gelation kinetics restrict their use in injectable applications such as the delivery...
Published: 6/19/2026
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Inventor(s): Stylianos Andreadis, Mohamed Alaa Eldein Mohamed
Keywords(s): Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines
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